Saturday, October 19, 2013

Mosque bombing kills 8 Sunni worshippers in northern Iraq


KIRKUK, Iraq (Reuters) - A bomb exploded near a mosque in the northern Iraqi city of Kirkuk on Tuesday, killing eight Sunni worshippers after the first prayer of the Muslim Feast of Sacrifice, or Eid al-Adha, police and medical sources said.


Insurgents usually intensify their attacks during religious holidays in Iraq, and security officials expect more violence over the coming days.


More than 6,000 people have been killed in bloodshed so far this year as Sunni Islamist and other insurgents regain ground and momentum in an onslaught against Iraq's Shi'ite-led government.


There was no immediate claim of responsibility for Tuesday's attack.


"I was on my way home nearby when I heard the explosion. I ran back to see what had happened and there were many killed and wounded people," said Ibrahim Mohammed. "There is drilling work on one of the mosque pillars and the bomb was placed there".


Fifteen people were wounded in the blast, said authorities.


Forced underground in 2007, al Qaeda's Iraqi wing has been reinvigorated by the civil war in neighboring Syria and growing resentment among the country's Sunni minority towards the Shi'ite-led government.


A raid by government security forces on a Sunni protest camp in April touched off a backlash by militants that still continues.


"These attacks, the latest in an upsurge of bombings, are particularly despicable as they hit Iraqis at a time when they extend their hands to the needy and the suffering on the occasion of Eid Al-Adha," said the spokesman for the Secretary-General of the United Nations.


(Reporting by Mustafa Mahmoud; Writing by Suadad al-Salhy; Editing by Andrew Heavens)



Source: http://news.yahoo.com/mosque-bombing-kills-8-sunni-worshippers-northern-iraq-072602909.html
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'Fifty Shades' fallout: Sources cite script showdown

Movies











21 hours ago

Image: Charlie Hunnam

Frazer Harrison / Getty Images file

Actor Charlie Hunnam, who currently stars on "Sons of Anarchy."

Universal Pictures and Focus Features haven't yet resorted to posting a woman-seeking-man personal ad on Craigslist. But in the wake of Charlie Hunnam's abrupt departure from "Fifty Shades of Grey" — after what sources say was increasing conflict with the high-profile film's creative team — the studio is left to scramble desperately for another actor to star opposite Dakota Johnson in the role of billionaire S&M fan Christian Grey so the project can meet a looming Nov. 1 start date.

PHOTOS: Stars Misaligned: Charlie Hunnam Quits 'Fifty Shades' and 15 Other Casting Near-Misses 

Universal chairman Donna Langley, producers Michael De Luca and Dana Brunetti, director Sam Taylor-Johnson and author EL James are said to have drafted a list of four men they want to read for the role. Although the list is being kept under NSA-level secrecy, THR.com revealed Oct. 13 that British TV stars Jamie Dornan, 31, and Christian Cooke, 26, are among the targets. Both actors came close to capturing the part the first time around but lost to Hunnam because the "Sons of Anarchy" star is a bigger name. ("True Blood's" Alexander Skarsgard also is being considered.)

Image: Jamie Dornan

Getty Images file

Actor Jamie Dornan.

Dornan could be emerging as a front-runner. Born in Northern Ireland, he's a former Calvin Klein model, dated Keira Knightley for two years and played Sheriff Graham on the first season of ABC's "Once Upon a Time." According to a source, Dornan was contacted by Langley even before Hunnam officially dropped out Oct. 12. But a Dornan confidant says no overtures had been made at press time to the actor, who stars in British series "The Fall," on which he plays a killer terrorizing Belfast. The fact that Dornan's wife, actress-singer Amelia Warner, is pregnant also could complicate matters.

PHOTOS: Top 10 Fan Favorites for the Cast of 'Fifty Shades of Grey' 

The last thing Universal wants is another actor to emerge as its "Fifty Shades" protagonist only to waffle. The studio is reeling over Hunnam's exit less than three weeks before the start of production. Sources say his discomfort with the hoopla around the project had been mounting for at least four weeks before he bailed, which officially was blamed on his "Sons" schedule not allowing him time to prepare (the FX series wraps production Oct. 22). After signing Sept. 2, Hunnam faced a public frenzy on social media sites, where fans of the book congregated to fawn over and complain about his casting. Universal was forced to hire bodyguards for the actor at a recent "Sons" premiere, and two appearances to promote the show were canceled — one at Goulet Motosports in Hawkesbury, Ontario, on Sept. 14, and one at Rocky's Harley-Davidson in London, Ontario, on Oct. 13.

In addition, Hunnam, who also is a writer (he penned the gothic horror screenplay "Vlad" for Brad Pitt's Plan B and Summit Entertainment), is said to have submitted his own very detailed script notes on Kelly Marcel's adaptation of the runaway best-seller. The notes were well received, according to sources, but that only led to Hunnam seeking further script approval, which was denied. "That's Charlie, that's who he is. He's particular," says one source.

STORY: Charlie Hunnam Drops Out of 'Fifty Shades of Grey' Movie 

According to another source, Hunnam, who was to be paid about $125,000 for the film, began butting heads with the creative team, including Taylor-Johnson. The conflict reached a fever pitch in early October, though everyone involved thought the issues had been resolved. But the discord spiked again Oct. 11. Hunnam's team at CAA and Brillstein Entertainment Partners strongly advised him to stay on the project for fear that his exit would embarrass Langley — new to the chairman job — and burn a bridge with one of the major studios. That same day, Universal hired writer Patrick Marber — no stranger to taboo sex themes with his Oscar-nominated screenplay "Notes on a Scandal" — to do a polish and bolster the characters. But by then, Hunnam, whose heart it seems never was in the project, had decided to decamp. The next morning, the studio announced his departure, and James tweeted, "I wish Charlie all the best." Universal and CAA declined comment.

Hunnam isn't the first actor to have doubts about playing the dungeon-loving Christian Grey. James' first choice, Robert Pattinson, never engaged with producers. Garrett Hedlund was heavily courted this summer and even received an informal offer, but the "Tron: Legacy" star passed in July because he couldn't connect with the character. Now he is in Australia to shoot the Angelina Jolie-directed "Unbroken."

EXCLUSIVE: 'Fifty Shades' Movie Hires Writer for Script Work

Fortunately for Universal, its leading lady, Johnson, 24, remains firmly in place, ready to take on the virgin-turned-sexpert Anastasia Steele, a role that has greater dimension than the Grey character. But with the clock ticking, the start of production likely will need to be pushed back at least a week. Still, the studio says it remains committed to making its Aug. 1, 2014, release date.

For her part, the ever-involved James (she has approval rights on cast) is in Los Angeles the week of Oct. 14 as the hunt for a new Christian Grey continues. As the author writes no fewer than 44 times in "Fifty Shades": "Oh my."

Borys Kit contributed to this report.








Source: http://www.today.com/entertainment/fifty-shades-fallout-sources-cite-charlie-hunnam-script-showdown-8C11401094
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Dell Venue 7 and 8 tablets now available online, starting at $150

Dell Venue tabletPowered by Clover Trail+ processors, these are very interesting budget tablets

Traditional PC maker Dell has released two new Android tablets, and starting today at their web shopping portal you can pick up the Dell Venue 7 for $150, or the Dell Venue 8 for $180.

Other than the screen size, the tablets are identical. Under the hood you have an Intel ATOM Z2580 processor, which is the high-end Clover Trail+ version that features Hyperthreading and VTx technology. This is paired with 2GB of RAM, and Intel HD graphics adapter, support for 802.11 b/g/n wireless and Bluetooth 4.0. The screen resolution is a mild 1200 x 800 on both the 7-inch Venue 7 and 8-inch Venue 8, and both tablets will ship with Android 4.2.2.

On paper, they appear to be solid consumer-grade offerings, which should have excellent battery life thanks to the Intel CPU. We've ordered one, and we'll have a look ourselves. At $150, it's certainly worth a good long look as the holiday shopping season approaches.

For more details and ordering information, see the source links.

Source: Dell. Thanks, Heath!


    






Source: http://feedproxy.google.com/~r/androidcentral/~3/vXme0TzGNGA/story01.htm
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How Women Saved Whiskey: An Instant Conversation





A woman places labels on Old Crow bourbon bottles sometime in the early 1900s.



Oscar Getz Museum of Whiskey History

Starter: Hello. Is that whiskey you're drinking?


Let me tell you about the debt that whiskey drinkers owe to women. Fred Minnick, a writer for the beverage industry, says so in his new book, Whiskey Women: The Untold Story of How Women Saved Bourbon, Scotch and Irish Whiskey.


Explainer: Women have played vital roles in the history of whiskey in America, Fred says. In the 19th century, "sex-selling saloon women created the greatest demand for American whiskey, peddling more than $2 million in booze in New York in 1857, while teetotaler temperance ladies fought to keep their cheating husbands from entering the brothels and saloons. The men blamed the whiskey; the wives fought for Prohibition."


Impressive Depth: You know all about Carrie Nation and the Women's Christian Temperance Movement, which led the charge for passage of the 18th Amendment and the National Prohibition Act of 1920.


But some women also led the battle cry to repeal Prohibition. Several historians have written about this, including Kenneth D. Rose in American Women and the Repeal of Prohibition and Daniel Okrent in Last Call: The Rise and Fall of Prohibition.


And now Fred. He says that Pauline Morton Sabin and her Women's Organization for National Prohibition Reform converted a bunch of erstwhile WCTU members into so-called "Repeal Women," who proclaimed that Prohibition favored the bootleggers and was disrespectful of the Constitution. Fred says, "Many politicians, most notably New York governor Herbert Lehman, credited Sabin for changing America's mind about Prohibition."


Quotes You Can Quote: Over the years, women have made their marks on Maker's Mark and other notable brands. Fred says that "without Marjorie 'Marge' Samuels inventing the red wax and the curvy bottle for Maker's Mark, bourbon packaging would still predominantly feature animals and old men. Samuels' design transformed the entire liquor industry."


Closer: This all reminds me of a memorable Walker Percy essay on bourbon in which the Southern semiotician writes about standing around with a couple of guys and knocking back two or three shots and the moment at which all three men said at once: "Where are the women?"


Maybe Fred's book answers the question: At least some of the women were busy saving bourbon from oblivion.


Ok, sure, I'll have a Shirley Temple.


What is The Protojournalist? New-school storytelling, old-school reporting. @NPRtpj


Source: http://www.npr.org/blogs/theprotojournalist/2013/10/18/236541835/how-women-saved-whiskey-an-instant-conversation?ft=1&f=1053
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Friday, October 18, 2013

Wheeldon's 'Cinderella': New twist on an old tale

This 2013 photo provided by the San Francisco Ballet shows, from left, Dores Andre, Sasha De Sola, Joan Boada and Wan Ting Zhao, in Wheeldon's "Cinderella." (AP Photo/San Francisco Ballet, Erik Tomasson)







This 2013 photo provided by the San Francisco Ballet shows, from left, Dores Andre, Sasha De Sola, Joan Boada and Wan Ting Zhao, in Wheeldon's "Cinderella." (AP Photo/San Francisco Ballet, Erik Tomasson)







This 2013 photo provided by the San Francisco Ballet shows Maria Kochetkova in Wheeldon's "Cinderella." (AP Photo/San Francisco Ballet, Erik Tomasson)







(AP) — Sure, "Cinderella" is a fairy tale. But still, wouldn't it feel just a tad more realistic if Cinderella and her Prince had a bit more time to get to know each other before falling madly in love? That meeting at the ball has always seemed a little, well, rushed.

That's just one of the intriguing variations that popular choreographer Christopher Wheeldon has made in his new "Cinderella," which hits New York's Lincoln Center next week, via the San Francisco Ballet. Here, Cinderella and the prince get to know each other a little before they even get to the ball, and Wheeldon gets to play up the parallels in their lives.

"I was interested in the idea that they have similar circumstances," says Wheeldon. "They meet and recognize similar qualities in each other. She's trapped in this familial environment that is vitriolic, whereas he's feeling trapped with his responsibilities. All he wants is to fall in love and be a normal guy. I thought of the royal princes today in the UK."

Just how the two meet before the ball, and who each think the other is, is better saved for the viewing. But it's not the only change Wheeldon has made to the most familiar ballet version: Frederick Ashton's, for the Royal Ballet in 1948. Wheeldon notes that he's based his version not on the lighter (and more familiar) Perrault version of the tale, but the later — and darker — Brothers Grimm version. As for the prince-Cinderella early meeting, he took that from the 19th-century Rossini opera. (The music, though, will be familiar to many: Wheeldon uses the well-known Prokofiev score.)

The 40-year-old British choreographer is one of the busiest in the business. Just this week, it was announced he'd be directing a new stage musical aimed at Broadway, "An American in Paris," based on the Oscar-winning film (a premiere is planned for December 2014 in Paris, with an eye to Broadway in 2015.) Wheeldon has the role of artistic associate at the Royal Ballet in London, but he's best known for his many works for New York City Ballet, where he also was a dancer.

"Cinderella," though, is from neither New York nor London. A joint production of the San Francisco Ballet, with which Wheeldon also has a long association, and the Dutch National Ballet, it premiered in Amsterdam last December and played in San Francisco in May, where it earned largely glowing reviews and sold out its run.

"Oh my gosh, standing room was five deep," says Helgi Tomasson, director of the San Francisco troupe. He attributes the popularity to several factors: enthusiasm for Wheeldon's work, advance word of its highly colorful and distinctive look, and, of course, the universally known story.

Indeed, it's a reality these days that the name "Cinderella" — or "Swan Lake," or "Nutcracker" — can fill a huge theater with eager families, and company directors need to consider the economics of the situation, particularly when creating a full-length production with elaborate sets and costumes. Still, say both Wheeldon and Tomasson, there's enough that's new and different about this "Cinderella" to more than justify a new version of the old tale.

"We all know Ashton's, but Chris wanted this one to be different," Tomasson says, "and he succeeded. Visually it's stunning to look at. The choreography is beautiful. And there's a real sense of magic in these changes that happen right before your eyes."

He's referring to the noted sets, which include, among many things, a tree that transforms into Cinderella's chariot to take her to the ball. That tree is connected to a central force of the story: Cinderella's late mother.

"The tree grows at Cinderella's mother's grave," Wheeldon says. "It becomes the magical essence of Cinderella's love for her mother." Also stemming from that tree are four "Fates," who together serve as a Fairy Godmother.

And what of the choreography? Principal dancer Sarah Van Patten, who plays Cinderella and, in other performances, one of the ugly stepsisters, says it feels "organic."

"You feel like you can breathe with the movement," she says. "It really comes across when the choreography makes you feel light."

"It's really stunning to watch," she adds of the entire production. "Even when I'm dancing it, I'm thinking, 'Wow, this is impressive.'"

_

Online:

www.sfballet.org

Associated PressSource: http://hosted2.ap.org/APDEFAULT/4e67281c3f754d0696fbfdee0f3f1469/Article_2013-10-18-Dance-Cinderella/id-906bcb3f599b4308ab2632c4cf2b24f2
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Is The U.S. In A Debt Crisis?


The Thursday deadline for raising the federal debt limit is fast approaching, but the government is still shut down. Host Michel Martin asks Sudeep Reddy of The Wall Street Journal and Time magazine's Rana Foroohar, if the U.S. is in a debt crisis.



Copyright © 2013 NPR. For personal, noncommercial use only. See Terms of Use. For other uses, prior permission required.


MICHEL MARTIN, HOST:


This is TELL ME MORE from NPR News. I'm Michel Martin. You might've been hearing the name Malala Yousafzai. She is the Pakistani teenager who was shot at point-blank range by Taliban extremists a year ago because she dared to speak up about her desire to go to school. She has made a remarkable recovery. She is in the U.S. now. I spoke with her a few days ago and we'll bring you a portion of that conversation a little later in the program.


But first, back to pressing matters in this country's politics. The United States is just days away from being unable to pay all of its bills and most government functions are still shut down. There are hints that an agreement is near, but either way, we were wondering if we are in a debt crisis now. Joining us to talk about this are Wall Street Journal economics reporter Sudeep Reddy. Also with us, Rana Foroohar. She's Time magazine's assistant managing editor for economics. Welcome back to both of you. Thank you both so much for speaking with us.


SUDEEP REDDY: Hi, Michel.


RANA FOROOHAR: Thank you.


MARTIN: Sudeep, as we are speaking to you now, we are fast approaching the deadline where Congress has to decide whether to hike the $16.7 trillion debt limit or the nation could - technically, the nation would be in default. So what would happen if this is not raised?


REDDY: If it's not raised, the United States will stop paying some of its bills and financial markets will probably go into the closest thing to panic we've seen since 2008. You're already seeing signs of that. Markets are preparing for a catastrophe. They're worried about a much more serious crisis than anything we've faced. And they're hoping that this will get resolved at the last minute as it usually does, but they're not betting anymore entirely that it will.


MARTIN: Rana, could you - now, obviously, you're in New York, which is, you know, a financial center, you know, of the country and one assumes that there's kind of a lot of awareness about that, but on practical terms, what will most people experience? Will people have - will people feel this actually in their own wallets? Rana?


FOROOHAR: Oh, I'm sorry. I was having trouble hearing you. Yeah, they will certainly feel it in their own wallets. And as a matter of fact, they already have. You can see consumer confidence has gone down. Business confidence is down, which means that companies are not spending, that has a dampening effect on employment. There are already estimates that the shutdown, so far, has shaved something like .3 percent off of growth this quarter. Of course, the situation gets more and more dire and the prognostications become more dire about what the result would be in terms of higher unemployment if we were to go over the debt ceiling and actually have a default. Now I do think that we have to caveat all of this by saying, though, that Thursday is not necessarily, you know, the cliff and once you're over it that's the end, you have another Lehman Brothers style event.


This is something that will roll out over days and weeks. There's actually a cushion of money in the Treasury. And so the Treasury does have a few more days after Thursday to pay bills. But of course every day you go over that debt ceiling, markets get more and more jittery. And you can see that in stock futures' prices.


MARTIN: Rana, stick with me here for a minute. There are those who argue that this is just the kind of tough love the economy needs. It's just like maxing out your own credit card. And if you've maxed out your own credit card, you just have to stop spending. Just stop charging. Is that - is that an appropriate analogy?


FOROOHAR: Well, you know, that's said in sort of two ways - I mean, on the one hand, people say, well, we've got to get our deficit in order, we've got this debt problem. The debt and the deficit are not even by a long shot our biggest economic problems right now. And what's ironic is that the deficit has actually been shrinking recently because of the sequester and because of all the fiscal cuts we've had from the last time we were in this situation in August of 2011.


I do think that you're probably going to have to see a stronger negative market signal in order for politicians to start to really feel the pressure and get their acts together and come towards a deal. I think it's interesting that that hasn't happened yet - and part of the issue here is that there is just a huge existential divide between Wall Street and Washington. You know, Wall Street cannot believe that there is this group of Republican politicians that are willing to sacrifice the economy for political gain. That's just something that the Street has a really hard time sort of coming to grips with. And I think you can see that psychic disconnect in the fact that we haven't seen more of a market reaction so far.


MARTIN: Sudeep, do you want to talk a little bit more about that, since you talk to a lot of these political folks all the time?


REDDY: They actually bring up the credit card analogy quite a bit. They feel like the United States government should be run like a family budget. That misses some very important facts. Primarily, that the United States government is the largest, most powerful government in the world and can borrow for a very long time. And people actually want to lend the U.S. government money. It is a safe haven in a crisis. Whenever you see any hint of fear in the market you see investors flooding into United States debt because that's the last thing you can trust in a crisis.


And that's one reason why you actually have interest rates go down in a crisis instead of - for the United States - instead of going up as you might see in some other countries. When you're the safe haven currency, you can borrow a lot longer. You have a lot more flexibility. The credit card analogy is useful to a point. If you've maxed out your credit card, if you've gone too far, if you feel like you could end up in bankruptcy down the road - you should start getting yourself on a payment plan. That's what these last three years have really been about. Talking about the longer run budget to try to maybe deal with the problems that we'll face a decade from now. But Rana's exactly right. The problem we have today is really weak economic growth. If we don't do something about that then whatever we do 10 years from now won't really matter.


MARTIN: If you're just joining us, we're talking about where we stand with the debt limit and also, you know, by extension, the government shutdown. Both of those issues seem to be wrapped up in the current kind of political discussions. Our guests are Sudeep Reddy. Wall Street Journal economics reporter. And Time magazine assistant managing editor for economics, Rana Foroohar.


Sudeep, Rana talked about kind of an existentialist distance between Wall Street - and I would say, by extension, kind of the business community and kind of the world of mainstream economics and the political leadership - at least the political leadership that's very invested in this fight. Do you see that as being true? I mean, why do you think that there's such a disconnect? I mean, traditionally people associated - at least in this era - the Republican party as being the party more closely tied to business and their priorities...


REDDY: That certainly has...


MARTIN: So why do you think that there's this disconnect?


REDDY: That certainly has traditionally been the case. What you're seeing today, and what you've been seeing since 2008, because of this incredibly weak economy - the weakest since the Great Depression, the slowest recovery we've had since World War II - people are looking at our government, at our economy and they see an existential threat to the nation. They are fighting this fight over the size and shape of government. And that's what the Tea party is all about.


That's what this new Republican base is all about. They see this as a fight to save the economy and save the country. And that's why they're so invested in it and saying, let's not look at the short-term gains of Wall Street, let's look at the big picture. What is too easy to forget - and nobody in America loves Wall Street unless you're around it and making money from it - what most people are seeing when they see Wall Street is they see lots of greed, they see lots of people making more money than they should be. And the lesson of 2008 though is that the financial system is the underpinning of the economy. And you saw these votes in 2008 where lawmakers would reject that premise and we're still dealing with the consequences. Billions of people's lives have been altered because of that decision and those decisions in 2008. And there is that disconnect. If you don't accept that the financial system is the underpinning of our economy then lots of bad things will happen.


MARTIN: Rana, there's also a school of thought that you should spend more during the time of recession, more. That the government should be spending more...


FOROOHAR: Yeah.


MARTIN: ...When their economy is slowing in order to stimulate that - that's kind of the, you know, operating economic philosophy in a number of other governments, you know, right now.


FOROOHAR: Sure.


MARTIN: To try to address this ongoing kind of economic stagnation. Does that point of view have any currency at all?


FOROOHAR: Oh, absolutely.


MARTIN: With the people you talk to, and why is it that it doesn't seem to have more force right now?


FOROOHAR: Well, it's a function of our partisan politics. I mean, if you looked at it, you know, particularly if you're sort of a liberal economist, that's absolutely the right way to look at things. That you want to spend. You want government to be a push - a sort of a push factor in the economy rather than a headwind. You know, if you stripped out all of the fiscal cutbacks in the government as part of the economy, you'd already be in a more robust recovery. Government, instead of helping, is actually hurting economy. So you can absolutely make that argument. The problem is that, you know, as we've seen time and time again over the last three years, we're in a situation where we're not having a discussion really about what's best for the economy.


We're having a very partisan, localized, political fight in Washington. And it really has nothing to do with what the best steps are for the economy. And I think it's fascinating - actually the point that Sudeep touched on - about how the Republican party is not necessarily the party of business anymore. I mean, when I talk to business leaders - CEOs around the country - their agenda is in some ways very much a left-leaning agenda. They want investment into infrastructure and education. They want the government to get over it and, you know, get Washington rolling again and stop having these every six months, every three months, debacles that cut our growth.


MARTIN: Sudeep, final thought from you. You know, there's been a lot of talk about how the recession in these past years - or at least the economic stagnation over the last couple of years has changed American families. It's changed people's thinking about what their priorities are. Some of their fiscal priorities - the way they spend money. Is there any sign that this current situation is kind of changing the way political leaders are thinking about the economy?


REDDY: Unfortunately, it's leading lawmakers to be more short-term in their thinking instead of long-term in their thinking. When you see this much pain and this much economic devastation around the country, the natural reaction is to want to do something immediately to help. That's one reason you have these battles about what can we do right now. If you talk to any economist who's dealing with countries around the world, they will always say the holy grail is coming up with structural changes. With coming up with changes to an economy that might take affect years down the line, maybe a decade down the line, but provide those very important signals of what's going to happen down the road and provide a stronger underpinning for the economy.


We've moved away from that because we are obviously in two-year election cycles and people are focused on that. And the pain is so severe, it's so raw, that it's leading people - lawmakers and their constituents - to think about what can we do right now and kind of push aside what you might be able to do that would be even more helpful down the line. If we had this discussion a few years ago, we'd obviously be better off.


MARTIN: Wall Street Journal economics reporter Sudeep Reddy was speaking just now. He was kind enough to join us in our Washington, D.C. studios. With us from the Time magazine studios in New York, Rana Foroohar. Assistant managing editor for economics for Time magazine. Thank you both so much for speaking with us.


REDDY: Thanks, Michel.


FOROOHAR: Thanks for having me.


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Source: http://www.npr.org/templates/story/story.php?storyId=234730454&ft=1&f=46
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Which Grandparent Are You Most Related to?

Illustration by Robert Neubecker.

Illustration by Robert Neubecker








What makes you who you are genetically? The easy answer is your family. The longer answer begins with the fact that all humans have two parents (at least for now), and usually four distinct grandparents (there are unfortunate exceptions). Genetically you are a recombination of four separate individuals. But that does not mean you have an equal contribution from four separate individuals. Humans normally carry 23 pairs of chromosomes: 22 autosomal pairs and one pair of sex chromosomes, either two copies of the X for a female or an X and a Y in the case of males. By Mendel’s law of segregation you receive one copy of each pair from your mother (via the egg), and one copy from your father (via the sperm). This means exactly half of your genome derives from each parent.














Things begin to get more complicated going back two generations. One might think that of the 44 autosomal chromosomes you would receive 11 from each of the four grandparents. (For simplicity we’ll leave the sex chromosomes out for now. If you are a female, you receive one X from each parent, while if you are a male you receive an X from your mother and a Y from your father, who got it from his father.) But while the proportion of one’s inheritance from parents is fixed by exact necessity, the fraction from grandparents is governed by chance. For each of the chromosomes you inherit from a given parent, you have a 50 percent chance of gaining a copy from your grandfather and a 50 percent chance of gaining a copy from your grandmother. The laws of independent probability imply that there is a 1-1,048 chance that all of your maternal or paternal chromosomes could come from just one grandparent! What’s more, genetic recombination means that chromosomes aren’t purely from one grandparent or the other; during the cell divisions that produce sperm and eggs, chromosomes exchange segments and become hybrids. You almost certainly have different genetic contributions from your four grandparents.










But this is not just abstract theorizing. Imagine that you could know that 22 percent of the genome of your child derives from your mother, and 28 percent from your father. Also imagine that you know that 23 percent of the genome of your child derives from your partner’s mother, and 27 percent derives from your partner’s father. And you could know exactly how closely your child is related to each of its uncles and aunts. This isn’t imaginary science fiction, it is science fact.












Last year, I sent a sample of my then 2-month-old daughter’s genetic material to the firm 23andMe and received her results. As it happens I already had the genotype of my daughter’s mother, father, all her uncles and aunts, and all four of her grandparents. In other words, her full pedigree was already available when her results came back, and she was easily slotted into the bigger genomic family photo album. Not only do I know which proportions of her ancestry derived from each grandparent, I know which regions of her genome derive from each of her grandparents. For example, one grandmother is half Norwegian, so genealogically my daughter isone-eighth Norwegian. But I quickly calculated using diverse data sets of various nationalities that genomically she is somewhat more than one-eighth Norwegian. This is reasonable as 28 percent of her ancestry, according to how her DNA analysis matches up with the DNA of the rest of the family, happens to come from her half Norwegian grandmother.










One might think these sorts of facts are useful only for the sake of satisfying curiosity, but sometimes theoretical knowledge can be put to practical use. Last spring my wife asked our pediatrician about testing my daughter for a treatable autosomal dominant condition which I happen to exhibit. The physician’s reaction was straightforwardly paternalistic. She would not authorize the test because she believed our daughter was too young. This did not sit well with my wife. The mutated gene which causes my condition has been well characterized. My wife went home and quickly used one of 23andMe’s features to find out if my daughter inherited a copy of the gene through me from my mother or my father. My mother is affected by the same ailment as I am, while my father is not. The happy ending is that my daughter almost certainly does not have the condition, because she inherited that genetic region from my father. The bigger moral of the story is that decentralized genetic information can allow persistence to pay off.










All of this is a consequence of the fact that I have an obsession with genetics. But it is also contingent on the fact that for less than $500, you can send in a kit and receive back a record of 1 million genetic variants in short order. This would have been unfathomable just 10 years ago. Out of 3 billion base pairs in the entire human genome, 1 million may not seem like much, but the ones tested were chosen because they vary across the population, and they represent a substantial proportion of the variable genome. Much of the information is banal, trivial, and redundant. My eyes are dark brown, and those of my wife are blue. Therefore, you will not be surprised to learn that a quick check on variants that code for eye color predicts that my daughter will shake out to have a light brown shade (as a matter of fact her eyes are light brown or hazel).


















Source: http://www.slate.com/articles/health_and_science/human_genome/2013/10/analyze_your_child_s_dna_which_grandparents_are_most_genetically_related.html
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